Novel Devices for Interfacing with Neurons


This research direction involves the use of conducting polymer devices to advance the state-of-the-art of neural prosthesis. We are developing probes that contain multi-sensing conducting polymer devices and that provide a wealth of information on brain function. We are also working on ultra-flexible electrodes, targeting implants that are conformable and will be minimally invasive. A collaboration with a leading INSERM group at la Timone hospital in Marseille provides us with key information on end-user requirements and allows us to test our probes in laboratory animals. A fundamental research component that deals with the understanding of ion exchange between neurons and conducting polymers complements this effort.		An implantable electrode array fabricated on a flexible substrate

Biosensors for Diagnostics, Toxicology and Drug Discovery


In this research direction we are leveraging the low-cost aspect of organic electronics to develop biosensors that are disposable. We are working on in vitro models that utilize live cells and ion channels as the recognition elements, and provide a way to reduce the use of laboratory animals in testing of pharmaceuticals, cosmetics, etc. A fundamental research component that deals with the formation of stable interfaces between the recognition element and the transducer complements this effort. A second fundamental research component deals with understanding the operation of the transducer, which is an organic electrochemical transistor.		A cell monolayer used as the bio- recognition element in a biosensor


In collaboration with the Fischbach group at Cornell, we exploit the ability of conducting polymers to be reversibly switched between reduced and oxidized states that present a different environment for cell growth. The aim is to fabricate electronic cell culture plates that control cell behavior and can be used as tools for biomedical research, as well as for antifouling surfaces.		Cell density gradient established on a conducting polymer surface